Results
| PMID | 24070183 |
| Gene Name | LAMC2 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 30 |
| Population details | 30 endometriosis patients with symptoms of dysmenorrhoea, chronic pelvic pain, dyspareunia, infertility, urinary and rectal symptoms |
| Age | 25 – 39 yrs |
| Sex | Female |
| Infertility type | Female infertility |
| Other associated phenotypes |
Endometriosis |
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Reprod Biol Endocrinol. 2013 Sep 26;11:94. doi: 10.1186/1477-7827-11-94. Locci, Rosella| Nisolle, Michelle| Angioni, Stefano| Foidart, Jean-Michel| Munaut, Carine Laboratory of Tumor and Development Biology, GIGA-Cancer, University of Liege, Tour de Pathologie (B23), Sart Tilman, B-4000 Liege, Belgium. c.munaut@ulg.ac.be. BACKGROUND: Endometrial cells, which are shed by retrograde menstruation, may aberrantly express molecules involved in invasion and migration, leading to endometriosis. The aim of this study was to investigate the expression of the laminin gamma 2 chain (LAMC2) in the tissues of women with and without endometriosis. METHODS: Endometrial biopsy specimens were collected from healthy volunteers and from endometriosis patients. Biopsy specimens from the corresponding endometriotic lesions were also collected. The expression of laminin gamma 2 chain was evaluated by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). RESULTS: Endometrial tissue from women with or without endometriosis showed constitutive expression of LAMC2 mRNA throughout the menstrual cycle. A higher mRNA level was observed in ectopic endometrium (Ec) from women with endometriosis compared with eutopic endometrium (Eu) from women with endometriosis. Immunohistochemistry revealed a varied pattern of laminin gamma 2 chain expression, with increased epithelial expression in eutopic endometrium from women with endometriosis compared with those without endometriosis. CONCLUSIONS: The altered expression of laminin gamma 2 chain in eutopic endometrium from women with endometriosis may provide new opportunities for diagnosis and treatment. Mesh Terms: Endometriosis/*metabolism| Endometrium/*metabolism| Female| Humans| Immunohistochemistry| Laminin/genetics/*metabolism| RNA, Messenger/metabolism| Reverse Transcriptase Polymerase Chain Reaction|DA 2014/09/03 06:00 |
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